基本信息
浏览量:145
职业迁徙
个人简介
Dr. Palmer Taylor's research has been directed to the structures, recognition capacities and regulation of expression of proteins governing neurotransmission in cholinergic synapses. His group cloned the first acetylcholinesterase (AChE) gene over 20 years ago, and this was followed by analysis of its genomic DNA to delineate regulatory regions, the multiple splicing options and gene expression profiles in nerve and muscle. His studies of AChE structure and its complexes by crystallographic and fluorescence methods, characterizing a peripheral site on AChE and the demonstrating flexibility of the active center gorge, provided the basis for collaborative studies with Barry Sharpless' group employing freeze-frame, click chemistry. The very biological target itself (AChE) is used as the template in the synthesis of high affinity, selective inhibitors.
Taylor's long standing work with nicotinic acetylcholine receptors (nAChR) defined ligand specificity in relation to state functions for receptor activation and desensitization and identified the structural determinants on nAChR governing ligand and peptide toxin specificity. More recently, his studies have been directed to the acetylcholine binding protein, a soluble surrogate of the receptor, whereby his group in collaboration with others, employed physical methods of fluorescence anisotropy decay, NMR, x-ray crystallography and denterium hydrogen exchange to examine structure and selectivity of the ligand binding sites. Finally, through collaborative endeavors, Taylor's group have uncovered much of what is known about the structure of neuroligin, a synaptic adhesion molecule homologous to AChE. Their structural studies on neuroligin have uncovered alterations in processing and folding associated with mutations found in the autistic spectral disorders.
研究兴趣
论文共 363 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Marine Drugsno. 4 (2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn