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职业迁徙
个人简介
As a competitive swimmer in my teenage years and early twenties I developed an interest in understanding muscle physiology and metabolism. This prompted me to pursue a PhD in exercise physiology at the University of Illinois. Shortly after completing this degree I returned to Canada to take up a faculty position (1973-1991) at Dalhousie University in Halifax. Quite quickly I realized that fundamental principles of muscle energetics, as these operate during exercise, could possibly be applied to examining biochemical problems in selected diseases. Specifically, it appeared to me that the inability to clear glucose from the blood (which is stream the key problem in type 2 diabetes), was probably due in large part to a defect in skeletal muscleÕs ability to take up glucose. This idea was initially quite controversial. However, over the years there has been widespread acceptance of this concept . During my years at the University of Waterloo (1991-2003) I began to probe the molecular mechanisms involved in regulating muscle glucose transport. In addition, my group has also introduced fundamental new understandings as to how fatty acids enter the cell, by a series binding proteins that can migrate to the cell membrane. This was also very controversial when first introduced, but this is now increasingly accepted. It now also appears that anomalies in this process of fatty acid uptake contribute directly to the problem of impaired glucose uptake by the muscle cell in type 2 diabetics. This work is continuing at the University of Guelph, where in 2003 I took up a position as a tier 1 Canada Research Chair in Metabolism and Health
I am a member of the Canadian Society for Exercise Physiology and the American Physiologic Society.
My research program is supported by grants from NSERC, CIHR (2), and the Heart and Stroke Foundation of Ontario.
I am a member of the Canadian Society for Exercise Physiology and the American Physiologic Society.
My research program is supported by grants from NSERC, CIHR (2), and the Heart and Stroke Foundation of Ontario.
研究兴趣
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Momken Iman,Adrian Chabowski, Ellen Dirkx,Nabben Miranda, Singh Swati, T Mcfarlan Jay, F C Glatz Jan, Luiken Joost J.F.P.,Bonen Arend
Biochemical Journalno. 1 (2017): 162
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PLOS ONEno. 5 (2015): 1
Arend Bonen,Swati S. Jain,Laelie A. Snook,Xiao-Xia Han,Yuko Yoshida, Kathryn H. Buddo,James S. Lally, Elizabeth D. Pask,Sabina Paglialunga,Marie-Soleil Beaudoin,Jan F. C. Glatz,Joost J. F. P. Luiken,
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