基本信息
浏览量:99
职业迁徙
个人简介
Our lab studies the causes and potential treatment for Alzheimer’s disease (AD) and stroke in animal models and in human subjects. We are trying to understand the cause of brain damage from AD stroke and to develop treatments based on our understanding of causes. We use rats to induce stroke damage and a variety of techniques, including molecular biology, behavioral assessment and drug interventions to determine the causes and potential treatment for stroke damage. Our work also involves the use of transgenic mouse models, primarily for modeling AD. West Virginia has one of the highest incidences of stroke in the nation and currently therapies to limit stoke damage are limited. Our lab therefore is searching for novel treatments that can limit the damage and/or improve recovery from stroke.
Research Interests:
We assess the role of mitochondria in stroke propensity and stroke damage. These studies are aims at identifying the mechanism by which mitochondrial dysfunction contributes to stroke damage and the possibility of targeting drugs to these mitochondrial defects as a therapy for prevention/acute treatment of stroke.
Assessment of vaious classes of drugs on neuroprotection in stroke and AD. We have a drug discovery program that attempts to discover novel compounds with efficacy in stroke and AD. One such class of compounds we have termed non-feminizing estrogens.
We assess the effects of beta amyloid on mitochondrial function to determine how this neurotoxic peptide causes loss of synapses and neurons in the brain.
研究兴趣
论文共 211 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Pharmaceuticals (Basel, Switzerland)no. 3 (2024): 270
Lincey Wilson, Duaa Dakhlallah, Anna Zukowski, Jacob Ralston,Kate Karelina,James Simpkins,Muhammad Alvi, Candace Brown
Saina Prabhu,Emily Burrage, Jenna Luthman, Crystal Oudomvilay, Natalia Luna,Ryan Childers, Alec Hanshew, Phillip Englund, Vincent Tierno, Jacob Hoover,James Simpkins,Eric Kelley,
PHYSIOLOGYno. S1 (2023)
引用0浏览0引用
0
0
iScienceno. 7 (2023): 106996-106996
EB Engler-Chiurazzi, AE Russel,JM Povroznik, K McDonald, K Porter, DS Wang,BK Billig,CC Felton, J Hammock,BG Schreurs,JD O’Callaghan,KJ Zwezdaryk,
biorxiv(2022)
biorxiv(2022)
Xuefang Sophie Ren,Huimahn A. Choi,Aaron M. Gusdon,Heng Hu,Jude Savarraj, Atzhiry Paz, Ryan S. Kitagawa,James W. Simpkins
Frontiers in Stroke (2022)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn