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职业迁徙
个人简介
Research Interests:
Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry. We discovered the first RNA demethylase and uncovered transcriptional and post-transcriptional gene expression regulation pathways mediated by dynamic RNA modifications such as N6-methyladenosine (m6A). We developed enabling methods to map DNA 5-hydroxymethylcytosine (5hmC) and its oxidation derivatives in mammalian genomes and invented new genomic methods to accurately monitor transcription and chromatin state. We revealed functional roles of DNA 6-methyladenosine (6mA) in eukaryotic genomes and studied metal ion homeostasis and selective metal ion recognition by naturally occurring and engineered proteins.
Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry. We discovered the first RNA demethylase and uncovered transcriptional and post-transcriptional gene expression regulation pathways mediated by dynamic RNA modifications such as N6-methyladenosine (m6A). We developed enabling methods to map DNA 5-hydroxymethylcytosine (5hmC) and its oxidation derivatives in mammalian genomes and invented new genomic methods to accurately monitor transcription and chromatin state. We revealed functional roles of DNA 6-methyladenosine (6mA) in eukaryotic genomes and studied metal ion homeostasis and selective metal ion recognition by naturally occurring and engineered proteins.
研究兴趣
论文共 1030 篇作者统计合作学者相似作者
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Nature cell biologyno. 3 (2024): 421-437
Nature Biotechnologypp.1-12, (2024)
RNA (New York, N.Y.) (2024)
Qing Dai,Chang Ye, Iryna Irkliyenko, Yiding Wang,Hui-Lung Sun,Yun Gao, Yushuai Liu,Alana Beadell, José Perea,Ajay Goel,Chuan He
Nature biotechnologypp.1-12, (2024)
Yongjie Ma,Zhe Ji,Wanxin Yang,Li Li, Liqiang Han, Yu Liu,Yuanhao Guo,Adam A. Dmytriw,Chuan He,Guilin Li,Hongqi Zhang
STAR PROTOCOLSno. 1 (2024): 102855-102855
Emir Malovic,Alyssa Ealy,Phillip J Hsu,Souvarish Sarkar, Cameron Miller,Dharmin Rokad, Cody Goeser, Aleah Kristen Hartman,Allen Zhu,Bharathi Palanisamy,Gary Zenitsky,Huajun Jin,
bioRxiv : the preprint server for biology (2024)
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