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职业迁徙
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Current Research and Scholarly Interests
We study the trafficking of white blood cells (lymphocytes, dendritic cells, monocytes, etc.), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, and their chemotactic responses in tissues. These events regulate immune responses by controlling the access of leukocytes to sites of inflammatory or immune reaction in the body. We identified an array of adhesion molecules or "homing receptors" that lymphocytes use to recognize organ (and/or inflammation)-specific vascular ligands or "addressins". The vascular addressins and adhesion receptors control immune cell recruitment, and thus local immune and inflammatory responses. We showed that adhesion receptors act coordinately with G protein-linked chemoattractant receptors in a multi-step process that controls the specificity and provides combinatorial diversity in leukocyte trafficking.
We study the trafficking of white blood cells (lymphocytes, dendritic cells, monocytes, etc.), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, and their chemotactic responses in tissues. These events regulate immune responses by controlling the access of leukocytes to sites of inflammatory or immune reaction in the body. We identified an array of adhesion molecules or "homing receptors" that lymphocytes use to recognize organ (and/or inflammation)-specific vascular ligands or "addressins". The vascular addressins and adhesion receptors control immune cell recruitment, and thus local immune and inflammatory responses. We showed that adhesion receptors act coordinately with G protein-linked chemoattractant receptors in a multi-step process that controls the specificity and provides combinatorial diversity in leukocyte trafficking.
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Nature Communicationsno. 1 (2024): 1-12
Romain Ballet, Melissa LaJevic,Noelle Huskey-Mullin, Rachel Roach,Kevin Brulois, Ying Huang,Muhammad A Saeed,Ha X Dang,Russell K Pachynski, Elizabeth Wilson,Eugene C Butcher,Brian A Zabel
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biorxiv(2022)
Thanh Theresa Dinh,Menglan Xiang,Anusha Rajaraman,Yongzhi Wang,Nicole Salazar, Walter Roper,Siyeon Rhee,Kevin Brulois,Ed O’Hara,Helena Kiefel, Truc Dinh,Yuhan Bi,
biorxiv(2022)
Thanh Theresa Dinh,Menglan Xiang,Anusha Rajaraman,Yongzhi Wang,Nicole Salazar,Yu Zhu, Walter Roper,Siyeon Rhee,Kevin Brulois,Ed O’Hara,Helena Kiefel, Truc M. Dinh,
biorxiv(2021)
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