基本信息
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职业迁徙
个人简介
My research interest over the past decade has focused on scaling up biochemical knowledge for gaining a deeper understanding of the molecular basis of neurodegenerative and neuropsychiatric disorders and finding ways to optimize their treatment. I have also made seminal contributions to the development of the metabolomics field and applications of metabolomics for the study of drug effects, establishing foundations for “Pharmacometabolomics”, a discipline that complements and informs pharmacogenomics and enables Precision Medicine initiatives. Over the next five years, I will continue to expand on these directions and applications of a systems biochemical approach, hoping to contribute in significant ways to President Obama’s Alzheimer’s Initiative as well as to Precision Medicine national and global initiatives. At the heart of my research is a deeper understanding of neuropsychiatric disease mechanisms, disease heterogeneity, and optimization of treatment for patients based on genotype, metabotype, microbiome activity and environmental influences and strategies for personalizing and optimizing treatment outcomes.
Areas of research in which I have made significant contributions include:
The study of metabolic impairments in neuropsychiatric diseases including depression, schizophrenia and Alzheimer’s disease.
Metabolomics technologies and applications for the study of human disease and treatment outcomes; helped create a community of metabolomics researchers.
Established foundations for “Pharmacometabolomics”, a new field for the application of metabolomics for the study of drug effects and variation of response to treatment as enabling tools for precision medicine. Contributed to the rapidly growing field of “Quantitative and Systems Pharmacology” by linking the metabolome and genome and drug response.
Made several discoveries on the role of the gut microbiome in neuropsychiatric diseases and response to treatment.
Helped move basic research from bench to clinic with discoveries concerning creatine kinase and energy impairment in neurodegenerative diseases.
研究兴趣
论文共 236 篇作者统计合作学者相似作者
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medrxiv(2024)
ADVANCED SCIENCEno. 9 (2024)
PROGRESS IN LIPID RESEARCH (2024): 101265-101265
medRxiv : the preprint server for health sciences (2024)
Scientific Reportsno. 1 (2023): 1-13
medRxiv : the preprint server for health sciences (2023)
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Heidi Isokääntä, Lucas Pinto da Silva,Naama Karu, Teemu Kallonen,Anna-Katariina Aatsinki,Thomas Hankemeier, Leyla Schimmel,Edgar Diaz,Tuulia Hyötyläinen,Pieter C. Dorrestein,Rob Knight,Matej Orešič,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
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