基本信息
浏览量:231
职业迁徙
个人简介
My research interests include clonal evolution in colorectal adenomas and inflammation-associated cancer, the nature of Barrett’s glands, and the design of methods to explore neutral drift in stem cell divisions in normal human tissues.
My work included designing methods for the analysis of stem cell biology in human tissues with the aim of understanding the role of stem cells in the maintenance of normal tissue architecture and the progression to malignancy.
We championed the use of mutations in mitochondrial and genomic DNA as clonal markers, and combined these with the analysis of methylation patterns in non-expressed genes to give a time dimension to the clonal expansion of stem cells in normal and malignant tissues.
Thus we have been able to show the location of the stem cell niche in a number of tissues, including the prostate, gastrointestinal and liver epithelia, and to explore clonal expansion of mutant clones in Barrett’s oesophagus, gastric intestinal metaplasia and colorectal adenomas.
We were also been able to follow the development of pre-tumour clones in the colon during pre-neoplastic evolution in Crohn’s disease and ulcerative colitis.
My work included designing methods for the analysis of stem cell biology in human tissues with the aim of understanding the role of stem cells in the maintenance of normal tissue architecture and the progression to malignancy.
We championed the use of mutations in mitochondrial and genomic DNA as clonal markers, and combined these with the analysis of methylation patterns in non-expressed genes to give a time dimension to the clonal expansion of stem cells in normal and malignant tissues.
Thus we have been able to show the location of the stem cell niche in a number of tissues, including the prostate, gastrointestinal and liver epithelia, and to explore clonal expansion of mutant clones in Barrett’s oesophagus, gastric intestinal metaplasia and colorectal adenomas.
We were also been able to follow the development of pre-tumour clones in the colon during pre-neoplastic evolution in Crohn’s disease and ulcerative colitis.
研究兴趣
论文共 987 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Charles Coombes, Christina Angelou, Zamzam Al-Khalili,William Hart, Darius Francescatti,Nicholas Wright,Ian Ellis,Andrew Green,Emad Rakha,Sami Shousha, Hemmel Amrania,Chris C. Phillips,
Breast Cancer Research and Treatmentpp.1-10, (2024)
Emanuela Carlotti,Adam M. Passman,Meng-Lay Lin, Shruthi Devkumar,Richard J. Hackett,Mairi McLean, Jo-Anne Chin Aleong,Timothy Underwood,Manuel Rodriguez-Justo,Marco Novelli,Nicholas A. Wright,Marnix Jansen,
GASTROENTEROLOGYno. 6 (2023): S1018-S1018
引用0浏览0引用
0
0
A.M. Passman,M.J. Haughey,E. Carlotti,M.J. Williams,B. Cereser, M.L. Lin, S. Devkumar, J.P. Gabriel,E. Gringeri,U. Cillo,F.P. Russo,M. Hoare,
Adam M. Passman,Emanuela Carlotti,Meng-Lay Lin, Shruthi Devkumar,Richard Hackett, Mairi H McLean, Timothy J. Underwood,Joanne Chin–Aleong,Manuel Rodríguez-Justo,Marco Novelli,Nicholas Wright,Marnix Jansen,
Gastroenterologyno. 6 (2023): S-1011
Richard J. Hackett,Emanuela Carlotti,Adam M. Passman, Shruthi Devkumar,Meng-Lay Lin,Maximilian Mossner, Freddie Whiting,Joanne Chin-Aleong,Manuel Rodriguez-Justo,Marnix Jansen,Laurence B. Lovat,Sean L. Preston,
GASTROENTEROLOGYno. 6 (2023): S42-S42
引用0浏览0引用
0
0
crossref(2023)
Charles Coombes, Hemmel Amrania, Christina Angelou, Zamzam Al-Khalili,Ian O. Ellis, Darius Francescatti,Chris Phillips,Andrew R. Green,Nicholas Wright,Emad A. Rakha,Carlo Palmieri
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023)
引用0浏览0引用
0
0
GASTROENTEROLOGYno. 6 (2023): S1011-S1011
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn