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职业迁徙
个人简介
Research Interests:
Protein aggregation in Alzheimer’s disease and related dementias
Protein self-assembly
Biologics and protein-based therapeutics
The Nath lab is interested in understanding the roles of protein dynamics in human health and disease. Proteins display a fascinating spectrum of dynamic behavior, ranging from some that are almost static to others that rapidly interconvert between a diverse ensemble of structures. The nature, amplitude and timescales of protein conformational fluctuations can be crucial to biological functions such as enzyme catalysis and intracellular signaling. Mutations, post-translational modifications and environmental factors can perturb protein dynamics – and hence normal function – in ways that are difficult to predict.
Abhi and his group are developing new and powerful methods to characterize and control protein dynamics, building on recent advances in biophysics, biochemistry and pharmacology from groups around the world. They focus on proteins involved in degenerative disorders (such as Alzheimer’s disease), the oxidative stress response, and drug metabolism.
Protein aggregation in Alzheimer’s disease and related dementias
Protein self-assembly
Biologics and protein-based therapeutics
The Nath lab is interested in understanding the roles of protein dynamics in human health and disease. Proteins display a fascinating spectrum of dynamic behavior, ranging from some that are almost static to others that rapidly interconvert between a diverse ensemble of structures. The nature, amplitude and timescales of protein conformational fluctuations can be crucial to biological functions such as enzyme catalysis and intracellular signaling. Mutations, post-translational modifications and environmental factors can perturb protein dynamics – and hence normal function – in ways that are difficult to predict.
Abhi and his group are developing new and powerful methods to characterize and control protein dynamics, building on recent advances in biophysics, biochemistry and pharmacology from groups around the world. They focus on proteins involved in degenerative disorders (such as Alzheimer’s disease), the oxidative stress response, and drug metabolism.
研究兴趣
论文共 83 篇作者统计合作学者相似作者
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Ellie I James,David W Baggett, Edcon Chang, Joel Schachter, Thomas Nixey, Karoline Choi,Miklos Guttman,Abhinav Nath
bioRxiv : the preprint server for biology (2024)
King Clyde B Yabut, Alice Martynova,Abhinav Nath, Benjamin P Zercher,Matthew F Bush,Nina Isoherranen
Molecular pharmacologypp.MOLPHARM-AR, (2024)
DRUG METABOLISM REVIEWSpp.1-19, (2024)
Archives of biochemistry and biophysics (2023): 109582-109582
Protein science : a publication of the Protein Societyno. 12 (2023)
Courtney Kunk, Josh Kruger, George Mendoza, Joey Markitan, Taylor Bias, Alexis Mann,Abhinav Nath,Werner J Geldenhuys,Michael A Menze,Mary E Konkle
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