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Bio
The major focus of our research effort concerns the mechanisms of obesity-induced metabolic diseases such as type 2 diabetes, which is a serious disease that affects 8.3% of the population in the United States. Currently we are using molecular biology, biochemical, and cell biology approaches as well as tissue-specific transgenic and knockout mouse models to identify and characterize key molecules involved in the regulation of glucose metabolism and energy homeostasis. Particularly we are interested in how obesity leads to adipocyte dysregulation and how adipose tissue dysfunction affects whole body energy homeostasis. It is our hope that better understanding of the mechanisms underlying the crosstalk between adipose tissues and other tissues will generate important information for the development of new therapeutic drugs for the treatment of obesity-associated disorders such as Type 2 diabetes, cancer, and aging.
Research Interests
Papers共 154 篇Author StatisticsCo-AuthorSimilar Experts
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Yaxing Liu, Jiahua Yuan, Yuling Zhang,Fei Qin, Xuemei Bai,Wanwei Sun,Tian Chen,Feng Liu, Yi Zheng,Xiaopeng Qi,Wei Zhao,Bingyu Liu,
CELL DEATH AND DIFFERENTIATIONno. 6 (2024): 1-15
Metabolism (2024): 155933-155933
Theranosticsno. 9 (2023): 3103-3116
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nature medicineno. 9 (2023): 2162-2165
JHEP reports : innovation in hepatologyno. 4 (2023): 100687-100687
The Journal of Clinical Endocrinology & Metabolismno. 7 (2023): 1824-1834
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