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Chen’s interests have recently shifted to ABC transporters involved in the immune system and disease. Her work on two such transporters, P-glycoprotein and MRP1, has led to new insights into a mechanism by which some cancer cells mount resistance to chemotherapy. Discovered in the 1970s, P-glycoprotein recognizes an array of structurally related compounds and pumps them out of the cell. It plays a Jekyll-and-Hyde role in human health: When the cell in question is cancerous and the compounds are therapies targeting some aspect of the cell’s internal machinery, P-glycoprotein’s action reduces the effectiveness of chemotherapy. But, by doing essentially the same thing, P-glycoprotein also helps maintain the integrity of the blood–brain barrier by keeping certain types of molecules from entering the central nervous system.
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Papers共 302 篇Author StatisticsCo-AuthorSimilar Experts
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Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2024): e2320879121-e2320879121
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 10 (2024): e2316675121-e2316675121
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 9 (2024): e2316673121-e2316673121
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Natureno. 7961 (2023): E11-E11
biorxiv(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2023)
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