基本信息
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职业迁徙
个人简介
Research Interests:
1. Decoding the genetic and epigenetic mechanisms of human aging
Combining primate models, stem cells, gene-editing techniques, single-cell sequencing and multi-omics analyses, we aim to study the genetic and epigenetic basis of human aging and aging-related diseases and explore new strategies for delaying aging (e.g. brain aging and cardiovascular aging) and for the prevention and treatment of aging-related diseases (e.g. neurodegenerative diseases and atherosclerosis) so as to achieve the goal of healthy aging.
2. Stem cell-based disease mechanism research and precision medicine on human diseases
Using patient-derived induced pluripotent stem cells (iPSC) and diseased embryonic stem cells (ESC) created in vitro, combined with directed differentiation and transplantation technologies, we aim to study molecular mechanisms and new targets of human diseases at the genome level, develop stem cell-based drug screening and evaluation systems, evaluate lead compounds that target specific targets of human diseases and promote the clinical and translational applications of stem cell-based technologies.
3. Development and application of new gene-editing methods and gene therapy technologies
On the basis of HDAdV, telHDAdV, TTALE and CRISPR/Cas9 techniques, we aim to develop new methods to safely and efficiently edit the human genome and establish new de-senescence and regenerative strategies via the applications of stem cells and new strategies for gene therapy, thus providing scientific basis for gene repair in rare diseases, genetic enhancement of human stem cells, and intervention of aging-related diseases.
研究兴趣
论文共 326 篇作者统计合作学者相似作者
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PROTEIN & CELLno. 1 (2024): 36-51
Zikai Zheng,Jiaming Li,Tianzi Liu,Yanling Fan, Qiao-Cheng Zhai,Muzhao Xiong,Qiao-Ran Wang, Xiaoyan Sun,Qi-Wen Zheng,Shanshan Che, Beier Jiang, Quan Zheng,
Protein & cell (2024)
Qiaoran Wang, Xuebao Wang, Beibei Liu,Shuai Ma, Feng Zhang, Shuhui Sun,Yaobin Jing,Yanling Fan,Yingjie Ding,Muzhao Xiong,Jiaming Li, Qiaocheng Zhai,
Nature Agingno. 3 (2024): 396-413
Shijia Bi,Xiaoyu Jiang,Qianzhao Ji,Zehua Wang,Jie Ren,Si Wang,Yang Yu, Ruoqi Wang,Zunpeng Liu, Junhang Liu,Jianli Hu,Guoqiang Sun,
Developmental Cell (2024)
Current Medicineno. 1 (2024): 1-5
Trends in pharmacological sciencesno. 2 (2024): 157-172
PROTEIN & CELLno. 2 (2024): 98-120
Phenomicsno. 1 (2024): 1-16
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