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Research in my lab focuses on ionic and molecular mechanism of neuronal cell death, neurovascular protection, neurogenesis, angiogenesis, and stem cell therapy using coordinated techniques in electrophysiology (whole-cell and single-channel patch-clamp recordings, brain slice recordings), cellular/molecular biology examinations and animal models of ischemic/traumatic injuries.
We are specialized in ion channel/transporter regulations under pathological conditions such as hypoxia and ischemia. The ion channel and transporter proteins under our investigation include voltage-gated K+ channels (e.g. Kv2.1, Kv1.5 and KCNQ channels), glutamate receptor channels (NMDA, AMPA and kainite receptors), and the Na+/K+-ATPase.
We are experienced in the investigation of molecular and cellular mechanisms of apoptosis; our in vitro and in vivo research has revealed the novel form of “hybrid cell death” of concurrent apoptosis and necrosis in the same cells after hypoxic and ischemic injury.
We have expertise in stem cell biology and the regulation of neuronal differentiation of these cells. Our research is focused on regenerative mechanisms that stimulate neurogenesis and angiogenesis related to the repair of neurovascular unit after brain disorders. My recent investigation developed the innovative technique of optochemogenetics and revealed a novel pathogenic mechanism of Alzheimer’s disease. Comprehensive functional and behavioral tests are performed in the lab to assess short- and long-term changes in locomotion, social interaction and cognitive activities after ischemic stroke, TBI, pain stimuli and in neurodegenerative rodent models.
We are specialized in ion channel/transporter regulations under pathological conditions such as hypoxia and ischemia. The ion channel and transporter proteins under our investigation include voltage-gated K+ channels (e.g. Kv2.1, Kv1.5 and KCNQ channels), glutamate receptor channels (NMDA, AMPA and kainite receptors), and the Na+/K+-ATPase.
We are experienced in the investigation of molecular and cellular mechanisms of apoptosis; our in vitro and in vivo research has revealed the novel form of “hybrid cell death” of concurrent apoptosis and necrosis in the same cells after hypoxic and ischemic injury.
We have expertise in stem cell biology and the regulation of neuronal differentiation of these cells. Our research is focused on regenerative mechanisms that stimulate neurogenesis and angiogenesis related to the repair of neurovascular unit after brain disorders. My recent investigation developed the innovative technique of optochemogenetics and revealed a novel pathogenic mechanism of Alzheimer’s disease. Comprehensive functional and behavioral tests are performed in the lab to assess short- and long-term changes in locomotion, social interaction and cognitive activities after ischemic stroke, TBI, pain stimuli and in neurodegenerative rodent models.
Research Interests
Papers共 259 篇Author StatisticsCo-AuthorSimilar Experts
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Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 9 (2023): 4267-4269
Molecular neurodegenerationno. 1 (2023): 43-29
Arteriosclerosis, thrombosis, and vascular biologyno. 7 (2023): 1281-1294
Neurodegenerative Diseasespp.1-12, (2023)
Nature Communicationsno. 1 (2023): 1-17
Research Square (Research Square) (2022)
Molecular Psychiatryno. 7 (2022): 3034-3046
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