Elevated Fab glycosylation of anti-hinge antibodies.

J Koers, Nil Derksen, Wjj Falkenburg,P Ooijevaar-de Heer,M T Nurmohamed,G J Wolbink,T Rispens

Scandinavian journal of rheumatology（2023）

引用 4|浏览20

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摘要

AHA responses are characterized by elevated levels of Fab glycosylation and highly specific neoepitope recognition, not just in RA patients but also in HCs. These results suggest that extensive Fab glycosylation may develop in response to an inflammatory proteolytic microenvironment, but is not restricted to RA.

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