Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Aysu Okbay,Bart M L Baselmans,Jan-Emmanuel De Neve,Patrick Turley,Michel G Nivard,Mark Alan Fontana,S Fleur W Meddens,Richard Karlsson Linnér,Cornelius A Rietveld,Jaime Derringer,Jacob Gratten,James J Lee,Jimmy Z Liu,Ronald de Vlaming,Tarunveer S Ahluwalia,Jadwiga Buchwald,Alana Cavadino,Alexis C Frazier-Wood, Nicholas A Furlotte,Victoria Garfield,Marie Henrike Geisel,Juan R Gonzalez,Saskia Haitjema,Robert Karlsson,Sander W van der Laan,Karl-Heinz Ladwig,Jari Lahti,Sven J van der Lee,Penelope A Lind,Tian Liu,Lindsay Matteson,Evelin Mihailov,Michael B Miller,Camelia C Minica,Ilja M Nolte,Dennis Mook-Kanamori,Peter J van der Most,Christopher Oldmeadow,Yong Qian,Olli Raitakari,Rajesh Rawal,Anu Realo,Rico Rueedi,Börge Schmidt,Albert V Smith,Evie Stergiakouli,Toshiko Tanaka,Kent Taylor,Gudmar Thorleifsson,Juho Wedenoja,Juergen Wellmann,Harm-Jan Westra,Sara M Willems,Wei Zhao,Najaf Amin,Andrew Bakshi,Sven Bergmann,Gyda Bjornsdottir,Patricia A Boyle,Samantha Cherney,Simon R Cox,Gail Davies,Oliver S P Davis,Jun Ding,Nese Direk,Peter Eibich,Rebecca T Emeny,Ghazaleh Fatemifar,Jessica D Faul,Luigi Ferrucci,Andreas J Forstner,Christian Gieger,Richa Gupta,Tamara B Harris,Juliette M Harris,Elizabeth G Holliday,Jouke-Jan Hottenga,Philip L De Jager,Marika A Kaakinen,Eero Kajantie,Ville Karhunen,Ivana Kolcic,Meena Kumari,Lenore J Launer,Lude Franke,Ruifang Li-Gao,David C Liewald,Marisa Koini,Anu Loukola,Pedro Marques-Vidal,Grant W Montgomery,Miriam A Mosing,Lavinia Paternoster,Alison Pattie,Katja E Petrovic,Laura Pulkki-Råback,Lydia Quaye,Katri Räikkönen,Igor Rudan,Rodney J Scott,Jennifer A Smith,Angelina R Sutin, Maciej Trzaskowski, Anna E Vinkhuyzen,Lei Yu, Delilah Zabaneh,John R Attia, David A Bennett,Klaus Berger,Lars Bertram,Dorret I Boomsma,Harold Snieder, Shun-Chiao Chang,Francesco Cucca,Ian J Deary,Cornelia M van Duijn,Johan G Eriksson,Ute Bültmann,Eco J C de Geus,Patrick J F Groenen,Vilmundur Gudnason,Torben Hansen, Catharine A Hartman, Claire M A Haworth,Caroline Hayward,Andrew C Heath, David A Hinds, Elina Hyppönen, William G Iacono,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L R Kardia,Liisa Keltikangas-Järvinen,Peter Kraft,Laura D Kubzansky,Terho Lehtimäki,Patrik K E Magnusson,Nicholas G Martin,Matt McGue,Andres Metspalu, Melinda Mills, Renée de Mutsert,Albertine J Oldehinkel,Gerard Pasterkamp,Nancy L Pedersen,Robert Plomin,Ozren Polasek, Christine Power,Stephen S Rich,Frits R Rosendaal,Hester M den Ruijter,David Schlessinger, Helena Schmidt, Rauli Svento,Reinhold Schmidt,Behrooz Z Alizadeh,Thorkild I A Sørensen,Tim D Spector,John M Starr,Kari Stefansson,Andrew Steptoe,Antonio Terracciano,Unnur Thorsteinsdottir, A Roy Thurik,Nicholas J Timpson,Henning Tiemeier,André G Uitterlinden,Peter Vollenweider,Gert G Wagner, David R Weir,Jian Yang, Dalton C Conley,George Davey Smith,Albert Hofman, Magnus Johannesson,David I Laibson,Sarah E Medland, Michelle N Meyer, Joseph K Pickrell,Tõnu Esko,Robert F Krueger, Jonathan P Beauchamp,Philipp D Koellinger,Daniel J Benjamin,Meike Bartels, David Cesarini

Nature Genetics（2016）

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摘要

Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high confidence, loci associated with each phenotype.

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