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The Breakefield laboratory is focusing on the use of molecular genetics to elucidate the genes underlying glioblastoma and to develop gene therapy strategies for brain tumors and schwannomas in the peripheral nervous system. This work involves development of novel vectors to enhance gene delivery/expression in tumors, and exploration of combined therapeutic modalities. We have used a number of viral vectors for gene delivery in culture and in vivo, and explored the nucleic acid content of extracellular vesicles (exosomes and microvesicles) released by neural cells, including their use as biomarkers in the serum and cerebral spinal fluid for brain tumors, ability to carry out intercellular communication among cells, and capacity to serve as therapeutic agents.
研究兴趣
论文共 669 篇作者统计合作学者相似作者
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Shilpa Prabhakar,Roberta L Beauchamp,Pike See Cheah,Akiko Yoshinaga,Edwina Abou Haidar,Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov,David H Jung,D Bradley Welling,Marco Giovannini,
Molecular therapy. Methods & clinical developmentno. 2 (2024): 101262-101262
MOLECULAR THERAPYno. 7 (2023): 2220-2239
Katia Maalouf, Dawn M. Frederick, Christine A. Vaine, D. Cristopher Bragg, Benjamin P. Kleinstiver,Xandra O. Breakefield,Koen Breyne
MOLECULAR THERAPYno. 4 (2023): 753-753
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crossref(2023)
Katia E Maalouf,Christine A Vaine, Dawn M Frederick,Akiko Yoshinaga, Wataru Obuchi,Shadi Mahjoum,Lisa Nieland,Jamal Al Ali,D Cristopher Bragg,Xandra O Breakefield,Koen Breyne
Molecular therapy : the journal of the American Society of Gene Therapyno. 7 (2023): 2206-2219
NEUROLOGYno. 17 (2023)
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Trevor D. McKee,Paola Grandi, Wilson Mok,George Alexandrakis, Numpon Insin, John P. Zimmer,Moungi G. Bawendi,Yves Boucher,Xandra O. Breakefield,Rakesh K. Jain
crossref(2023)
Thomas S. van Solinge, Kristina Pagh Friis,Killian O'Brien, Romy L. Verschoor, Jeroen van Aarle, Arnold Koekman,Xandra O. Breakefield,Pieter Vader,Raymond Schiffelers,Marike Broekman
International Journal of Pharmaceutics: X (2023): 100191-100191
biorxiv(2023)
Elsevier eBookspp.713-751, (2023)
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