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Living things are made up of one or more cells, and cells need membranes to provide barriers inside the cell and protect them from the outside world. Whilst the biological membranes that form these barriers are incredibly complex and diverse in nature, they are generally characterised by a lipid bilayer studded with many proteins. In order to make new membranes, the cell has to put new proteins into the lipid bilayer, and in higher organisms this is one of the key functions of a specialised cellular compartment known as the endoplasmic reticulum. The endoplasmic reticulum contains a number of molecular machines that stitch new proteins into the lipid bilayer to make functional membranes. One of our major objectives is to understand how this process works with complete molecular detail. It is also clear that this process can go wrong, and when it does so this is often linked to diseases such as cystic fibrosis. Understanding how defects in newly made membrane proteins are recognised, and defining the consequences that this can have for the cell, is the second of our major research goals.
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论文共 154 篇作者统计合作学者相似作者
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Joan Chang,Adam Pickard, Jeremy A. Herrera, Sarah O’Keefe, Matthew Hartshorn,Richa Garva, Anna Hoyle, Lewis Dingle,Cédric Zeltz,Jason Wong, Adam Reid,Rajamiyer V. Venkateswaran,
biorxiv(2024)
The EMBO journalno. 17 (2023)
Sarah O'Keefe, Quentin P. Roebuck,Izumi Nakagome,Shuichi Hirono,Atsushi Kato,Robert Nash,Stephen High
GLYCOBIOLOGYno. 7 (2023): 530-542
Sarah O'Keefe,Pratiti Bhadra,Kwabena Duah,Guanghui Zong, Levise Tenay,Lauren Andrews,Hayden Schneider, Ashley Anderson,Zhijian Hu,Hazim Aljewari,Belinda Hall,Rachel Simmonds,
crossref(2022)
Hazel Stewart,Yongxu Lu, Sarah O’Keefe,Anusha Valpadashi, Luis Daniel Cruz-Zaragoza,Hendrik A. Michel, Samantha K. Nguyen,George W. Carnell, Nina Lukhovitskaya, Rachel Milligan,Irwin Jungreis, Valeria Lulla,
biorxiv(2022)
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